- Factor V Leiden is an inherited blood clotting disorder. It is a specific gene mutation that can result in thrombophilia (an abnormality of blood coagulation that increases the risks of blood clots forming in blood vessels).
- People who are heterozygous (carry one gene mutation) or homozygous (carry two gene mutations) are at higher risk of developing a DVT (deep vein thrombosis).
- Factor V Leiden is the most common clotting disorder. 3-8% of Caucasians in North America carry the gene mutation.
- Factor V Leiden can cause miscarriages. Pregnant women with Factor V are considered high risk and need to be on a course of low molecular heparin or it’s derivative, Enoxaparin Sodium (generic name is Lovenox), during pregnancy.
WHAT ISN’T WIDELY DISCUSSED/KNOWN
- Factor V Leiden along with other blood clotting disorders has been DIRECTLY linked to Osteonecrosis/Avascular Necrosis. There are several clinical papers I have included on this blog concerning this fact.
- If you have Factor V you should NEVER take steroids. Even a 20 day use of high dose Prednisone can cause ON/AVN.
- If you have Factor V NEVER take drugs with estrogen, ie, the Pill.
- If you have Factor V NEVER eat products that advertise themselves as containing phytoestrogen.
Note: The above are direct recommendations given to me during a meeting with Dr. Charles Glueck and are supported by his research.